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Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics@the study of all small molecules or metabolites in a biological system@to connect a motherfs phthalate exposure to a newbornfs metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
gThis represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,h added Liang, an associate professor of environmental health at Emory Universityfs Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, childrenfs toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

gWe conducted this study because phthalates are everywhere in our daily lives,h Liang said, hence their nickname geverywhere chemicals.h

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